TB-Profiler result

Run: ERR4817475
Summary

Run ID: ERR4817475

Sample name:

Date: 20-10-2023 08:24:17

Number of reads: 4101398

Percentage reads mapped: 95.4

Strain: lineage4.1.1.3

Drug-resistance: Other

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin R rrs n.888G>A (0.72)
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.72 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 0.99
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.56
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.19
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.2
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.49
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.63
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.79
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.8
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.8
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.8
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.8
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.79
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.3
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.48
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.3
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.94
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.78
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.78
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.25
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.56
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.31
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.61
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.7
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.7
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.15
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.7
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.26
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.66
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.65
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.62
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.46
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.76
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.7
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.7
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.93
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.9
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.9
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.73
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.66
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.81
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.81
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.7
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.7
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.67
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.64
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.52
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.47
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.42
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.53
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.51
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.53
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.33
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.55
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.2
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.48
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.46
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.43
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.43
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.38
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.38
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.33
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.41
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.64
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.58
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.48
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.52
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102427 p.Ser206Pro missense_variant 1.0
PPE35 2169443 c.1170T>C synonymous_variant 0.98
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 0.97
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249408 c.2895G>A synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0