TB-Profiler result

Run: ERR4817623
Summary

Run ID: ERR4817623

Sample name:

Date: 01-04-2023 15:06:08

Number of reads: 1366335

Percentage reads mapped: 98.34

Strain: lineage4.6.2.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.2 Euro-American T;LAM RD726 1.0
lineage4.6.2.2 Euro-American (Cameroon) LAM10-CAM RD726 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576751 p.Lys468Asn missense_variant 0.27
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 778298 c.-692C>T upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.11
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.12
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.12
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.12
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.23
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.13
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.33
rrs 1472158 n.313C>T non_coding_transcript_exon_variant 0.13
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.2
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.14
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.3
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.5
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.75
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.75
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.6
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.5
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.6
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.38
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.4
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.4
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.4
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.3
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.4
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.3
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.33
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.4
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.3
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.36
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.5
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.6
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.6
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.5
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.18
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.27
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.36
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.23
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.33
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.17
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.33
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.31
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.31
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.31
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.31
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.14
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.17
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.17
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.17
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.17
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.15
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.23
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.22
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.42
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.21
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.2
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.27
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.19
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155389 c.723C>G synonymous_variant 1.0
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ahpC 2726338 p.Val49Gly missense_variant 0.43
thyX 3067474 p.Pro158Ala missense_variant 1.0
Rv3083 3448567 p.His22Asp missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612571 c.546C>T synonymous_variant 1.0
embA 4242550 c.-683C>G upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
aftB 4267272 p.Lys522Arg missense_variant 1.0
ethR 4326739 c.-810G>C upstream_gene_variant 1.0
ethA 4328004 c.-531C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0