TB-Profiler result

Run: ERR4817754
Summary

Run ID: ERR4817754

Sample name:

Date: 01-04-2023 15:10:29

Number of reads: 286032

Percentage reads mapped: 92.28

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
fgd1 491014 p.Thr78Pro missense_variant 0.22
fgd1 491027 p.Asn82Thr missense_variant 0.33
ccsA 620380 p.Met164Val missense_variant 0.33
rpoB 759898 p.Asn31Thr missense_variant 0.18
rpoB 761835 p.Cys677Arg missense_variant 0.29
rpoC 765727 c.2358T>C synonymous_variant 0.29
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776092 p.Ser797Cys missense_variant 0.18
mmpL5 776287 p.Ile732Val missense_variant 0.12
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.29
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1674076 p.Thr213Pro missense_variant 0.33
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102540 p.Ala168Gly missense_variant 0.25
ndh 2102623 c.420C>T synonymous_variant 0.18
katG 2155895 p.Val73Ile missense_variant 0.15
katG 2156045 p.Val23Leu missense_variant 1.0
PPE35 2167898 c.2715G>C synonymous_variant 0.17
PPE35 2167901 c.2712T>C synonymous_variant 0.17
PPE35 2168304 p.Thr770Met missense_variant 0.18
PPE35 2169488 c.1125G>C synonymous_variant 0.2
PPE35 2169491 c.1122T>C synonymous_variant 0.2
Rv1979c 2221889 p.Val426Ile missense_variant 0.2
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2715036 c.297G>A synonymous_variant 0.13
Rv2752c 3065090 p.Ala368Ser missense_variant 0.14
thyX 3067986 c.-42delC upstream_gene_variant 0.29
thyX 3068115 c.-170C>T upstream_gene_variant 0.25
ald 3086634 c.-186T>C upstream_gene_variant 0.13
fbiA 3641129 p.Ala196Val missense_variant 1.0
ddn 3987022 p.Arg60Pro missense_variant 0.2
embC 4239821 c.-42C>T upstream_gene_variant 0.15
ethA 4327061 p.Ser138Thr missense_variant 0.18
whiB6 4338595 c.-75delG upstream_gene_variant 1.0