TB-Profiler result

Run: ERR4817963

Summary

Run ID: ERR4817963

Sample name:

Date: 01-04-2023 15:17:23

Number of reads: 530762

Percentage reads mapped: 99.95

Strain: lineage4.9

Drug-resistance: Sensitive


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 9057 p.Glu586* stop_gained 0.1
gyrA 9122 c.1821C>G synonymous_variant 0.11
gyrA 9230 c.1929T>C synonymous_variant 0.14
ccsA 620619 c.729G>A synonymous_variant 0.12
ccsA 620669 p.Gly260Asp missense_variant 0.1
rpoB 760180 p.Ala125Asp missense_variant 0.14
rpoB 761448 p.Phe548Leu missense_variant 0.15
rpoB 762721 p.Asp972Gly missense_variant 0.2
rpoC 765795 p.Gly809Asp missense_variant 0.29
fbiC 1304370 c.1440G>T synonymous_variant 0.33
fbiC 1304792 p.Val621Ala missense_variant 0.11
Rv1258c 1406496 p.Ala282Asp missense_variant 0.12
embR 1416198 p.Thr384Ala missense_variant 0.11
atpE 1461092 c.48C>T synonymous_variant 0.29
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473440 n.-217_-216delTG upstream_gene_variant 0.14
rrl 1473535 n.-123C>T upstream_gene_variant 0.18
ndh 2101848 c.1195C>T synonymous_variant 0.12
katG 2153910 c.2202C>T synonymous_variant 0.17
eis 2715555 c.-223G>A upstream_gene_variant 0.17
folC 2746915 c.684G>A synonymous_variant 0.22
ribD 2986842 p.Pro2Ser missense_variant 0.14
thyX 3067682 c.264G>C synonymous_variant 0.15
thyX 3067685 c.261A>G synonymous_variant 0.15
thyX 3067688 c.258G>C synonymous_variant 0.15
thyX 3067694 c.252G>C synonymous_variant 0.15
thyX 3067718 c.228C>G synonymous_variant 0.12
thyX 3067721 c.225T>C synonymous_variant 0.12
thyX 3067724 c.222G>A synonymous_variant 0.1
thyX 3067727 c.219A>C synonymous_variant 0.1
thyX 3067739 c.207T>C synonymous_variant 0.11
thyX 3067742 c.204A>C synonymous_variant 0.12
thyA 3074389 p.Ser28Thr missense_variant 0.2
fprA 3474561 c.555G>A synonymous_variant 0.18
whiB7 3568431 c.249C>A synonymous_variant 0.2
Rv3236c 3613146 c.-30T>C upstream_gene_variant 0.18
fbiB 3641803 p.Asp90Val missense_variant 0.25
rpoA 3878095 p.Leu138Pro missense_variant 0.15
embC 4240705 c.843G>T synonymous_variant 0.18
embA 4244646 c.1414C>A synonymous_variant 0.15
embB 4248352 p.Leu613Phe missense_variant 0.15
ubiA 4269545 p.Val97Met missense_variant 0.14