TB-Profiler result

Run: ERR4818124
Summary

Run ID: ERR4818124

Sample name:

Date: 01-04-2023 15:22:58

Number of reads: 851912

Percentage reads mapped: 99.91

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5898 p.Asp220Val missense_variant 0.13
fgd1 491368 p.Ser196Thr missense_variant 0.18
mshA 576149 p.Val268Leu missense_variant 0.12
mshA 576152 p.Ala269Pro missense_variant 0.12
ccsA 620386 p.Ala166Thr missense_variant 0.15
rpoB 760999 p.Met398Thr missense_variant 0.14
rpoB 761534 c.1732delC frameshift_variant 0.11
rpoB 761903 c.2097T>C synonymous_variant 0.11
rplC 801368 p.Ala187Asp missense_variant 0.14
fbiC 1304487 c.1557C>T synonymous_variant 0.15
fbiC 1304969 p.Leu680Pro missense_variant 0.14
embR 1416629 p.Gly240Val missense_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1474461 n.804A>T non_coding_transcript_exon_variant 0.67
rrl 1475853 n.2196C>T non_coding_transcript_exon_variant 0.14
fabG1 1673867 p.Gly143Asp missense_variant 0.17
fabG1 1674064 p.Lys209Glu missense_variant 0.25
inhA 1674897 p.Met232Ile missense_variant 0.14
katG 2154047 p.Trp689Arg missense_variant 0.11
PPE35 2167868 c.2745A>C synonymous_variant 0.2
pncA 2289830 c.-589G>A upstream_gene_variant 0.14
kasA 2518681 p.Asp189Glu missense_variant 0.12
Rv2752c 3066107 p.Arg29Cys missense_variant 0.25
thyX 3067349 c.597G>A synonymous_variant 0.14
thyA 3073970 p.Ala168Pro missense_variant 0.12
Rv3083 3449527 p.Ile342Val missense_variant 0.13
fprA 3474273 p.Gln89His missense_variant 0.15
fprA 3475101 c.1095C>T synonymous_variant 0.14
fbiB 3642036 p.Ala168Ser missense_variant 0.13
fbiB 3642771 p.Asp413Tyr missense_variant 0.12
rpoA 3878554 c.-47C>T upstream_gene_variant 0.67
clpC1 4038245 p.Phe820Leu missense_variant 0.14
embC 4239985 c.123T>C synonymous_variant 0.13
embC 4241294 p.Ala478Ser missense_variant 0.13
embC 4241652 p.Ala597Val missense_variant 0.17
embB 4246602 p.Ala30Val missense_variant 0.13
embB 4246799 p.Gly96Arg missense_variant 0.15
embB 4246831 c.320delA frameshift_variant 0.11
embB 4248726 p.Ser738Tyr missense_variant 0.12
aftB 4268023 p.Leu272Met missense_variant 0.14
ethA 4327830 c.-357G>A upstream_gene_variant 0.12
whiB6 4338238 p.Leu95Pro missense_variant 0.15
whiB6 4338268 p.Gly85Val missense_variant 0.15
gid 4407814 p.Gly130Asp missense_variant 0.17