TB-Profiler result

Run: ERR4818364
Summary

Run ID: ERR4818364

Sample name:

Date: 20-10-2023 08:38:59

Number of reads: 4782973

Percentage reads mapped: 99.16

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.55
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.66
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.57
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.53
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.67
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.67
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.67
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.8
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.8
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.8
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.93
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.93
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.93
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.85
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.72
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.71
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.71
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.69
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.69
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.65
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.65
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.67
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.81
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.74
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.77
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.81
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.7
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.7
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.44
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714830 p.Pro168His missense_variant 1.0
ald 3087747 p.Thr310Ala missense_variant 1.0
fbiB 3641535 c.1T>G start_lost 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0