TB-Profiler result

Run: ERR4818743

Summary

Run ID: ERR4818743

Sample name:

Date: 01-04-2023 15:43:37

Number of reads: 1012615

Percentage reads mapped: 99.87

Strain: lineage4.9

Drug-resistance: Other


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpsA 1834961 p.Arg474Trp missense_variant 0.11 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5891 p.Val218Phe missense_variant 0.13
ccsA 620748 c.858T>G synonymous_variant 0.27
fbiC 1303017 c.87A>G synonymous_variant 0.16
fbiC 1304136 c.1206C>G synonymous_variant 0.19
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472400 n.555C>A non_coding_transcript_exon_variant 0.13
rrs 1472553 n.708C>A non_coding_transcript_exon_variant 0.17
rrl 1476092 n.2435A>G non_coding_transcript_exon_variant 0.25
tlyA 1917781 c.-159G>T upstream_gene_variant 0.11
PPE35 2169673 p.Ser314Thr missense_variant 0.12
Rv1979c 2222372 p.Ala265Pro missense_variant 0.17
Rv1979c 2222664 c.501G>T synonymous_variant 0.11
kasA 2518147 c.33C>T synonymous_variant 0.15
clpC1 4039484 c.1221T>G synonymous_variant 0.29
embC 4240648 c.786C>T synonymous_variant 0.18