TB-Profiler result

Run: ERR4819280
Summary

Run ID: ERR4819280

Sample name:

Date: 2024-10-04T00:01:24.702800

Number of reads: 243141

Percentage reads mapped: 72.31

Median coverage: 4.0

Strain: lineage4.1.1.1;lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.26
lineage4.1.1.1 Euro-American (X-type) RD183 0.52
lineage4 Euro-American None 0.99
lineage4.1.1 Euro-American (X-type) None 0.49
lineage4.9 Euro-American (H37Rv-like) None 0.69
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
clpC1 4039064 c.1641C>T synonymous_variant 0.58 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.7 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.7 pyrazinamide
embC 4240897 c.1035C>G synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.85 ethambutol Not assoc w R