TB-Profiler result

Run: ERR4819495
Summary

Run ID: ERR4819495

Sample name:

Date: 01-04-2023 16:08:30

Number of reads: 111629

Percentage reads mapped: 87.98

Strain: lineage4

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 1.0 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
embB 4247552 p.Ser347Cys missense_variant 0.33 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5165 c.-75C>G upstream_gene_variant 1.0
gyrA 8060 p.Met253Ile missense_variant 0.67
rpoB 760880 c.1076_1077delTG frameshift_variant 0.5
rpoB 762716 c.2912delT frameshift_variant 0.5
rpoC 764018 p.Asp217His missense_variant 0.5
mmpL5 775639 p.Ile948Val missense_variant 1.0
fbiC 1305363 c.2433G>T synonymous_variant 0.5
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 1.0
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 1.0
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 1.0
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 1.0
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 1.0
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 1.0
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 1.0
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 1.0
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 1.0
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 1.0
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.4
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.4
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.5
Rv2752c 3065228 p.Glu322Lys missense_variant 0.4
fbiB 3642382 p.Ala283Asp missense_variant 0.29
panD 4044119 p.Leu55Met missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0