Run ID: ERR4819552
Sample name:
Date: 2024-04-16T12:35:38.579318
Number of reads: 2532710
Percentage reads mapped: 99.62
Median coverage: 77.0
Strain: lineage4.8
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.8 | Euro-American (mainly T) | RD219 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
rpoB | 761967 | p.Glu721Lys | missense_variant | 1.0 | rifampicin | Uncertain significance |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
PPE35 | 2169071 | c.1463_1541delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNA | frameshift_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2169122 | c.1491C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
PPE35 | 2169125 | c.1486_1488delGTTinsAC | frameshift_variant&missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2169131 | c.1482C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
PPE35 | 2169134 | c.1479G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
PPE35 | 2169141 | p.Thr491Met | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2169144 | p.Val490Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2169149 | c.1464G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
pncA | 2289972 | c.-731T>G | upstream_gene_variant | 0.98 | pyrazinamide | |
kasA | 2518169 | p.Val19Ile | missense_variant | 1.0 | isoniazid | |
ald | 3087095 | c.276C>T | synonymous_variant | 1.0 | cycloserine | |
Rv3083 | 3448507 | c.5_*1408del | frameshift_variant&stop_lost&splice_region_variant | 1.0 | ethionamide | Uncertain significance |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R |