TB-Profiler result

Run: ERR501644
Summary

Run ID: ERR501644

Sample name:

Date: 01-04-2023 21:48:28

Number of reads: 138307

Percentage reads mapped: 97.81

Strain:

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
pncA 2288952 p.Gly97Asp missense_variant 0.4 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5801 p.Glu188Lys missense_variant 0.33
gyrA 7294 c.-8A>T upstream_gene_variant 0.25
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575676 p.Arg110Leu missense_variant 0.67
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775862 c.2619G>A synonymous_variant 0.5
mmpL5 776624 p.Asn619Lys missense_variant 0.22
mmpS5 779615 c.-710C>G upstream_gene_variant 0.67
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 0.67
atpE 1460888 c.-157C>T upstream_gene_variant 0.5
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472908 n.1063G>T non_coding_transcript_exon_variant 0.5
rrl 1475188 n.1531C>T non_coding_transcript_exon_variant 0.5
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917915 c.-24_-22delCGG upstream_gene_variant 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155578 p.Phe178Leu missense_variant 0.5
katG 2156334 c.-223G>A upstream_gene_variant 0.5
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168890 p.Ala575Thr missense_variant 0.29
PPE35 2170632 c.-20A>G upstream_gene_variant 0.67
Rv1979c 2222032 p.Ala378Val missense_variant 0.4
Rv1979c 2223014 p.Tyr51Asn missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746269 p.Thr444Ser missense_variant 0.67
folC 2746809 p.Ala264Ser missense_variant 0.22
pepQ 2860582 c.-164A>T upstream_gene_variant 0.4
Rv2752c 3065652 c.540C>T synonymous_variant 0.33
fprA 3473966 c.-40delC upstream_gene_variant 0.33
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiA 3641099 p.Ala186Asp missense_variant 0.5
alr 3840630 p.Pro264Leu missense_variant 0.67
alr 3841586 c.-166G>A upstream_gene_variant 1.0
rpoA 3877944 c.564C>T synonymous_variant 0.33
embC 4239775 c.-88G>A upstream_gene_variant 0.67
embC 4242425 p.Arg855Gly missense_variant 0.33
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embB 4248115 c.1602C>T synonymous_variant 1.0
embB 4248295 p.His594Gln missense_variant 0.67
aftB 4268831 c.6C>A synonymous_variant 1.0
ubiA 4269116 p.Arg240Cys missense_variant 0.29
ubiA 4269775 p.Ala20Val missense_variant 0.4
ethR 4326622 c.-927C>T upstream_gene_variant 0.5
ethA 4326881 p.Gly198Val missense_variant 0.29
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407669 p.Met178Ile missense_variant 0.5
gid 4407927 p.Glu92Asp missense_variant 1.0