TB-Profiler result

Run: ERR5864140
Summary

Run ID: ERR5864140

Sample name:

Date: 01-04-2023 23:08:49

Number of reads: 288306

Percentage reads mapped: 99.35

Strain: lineage2.2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2154463 p.Ala550Asp missense_variant 0.22 isoniazid
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289072 p.His57Arg missense_variant 1.0 pyrazinamide
embA 4243222 c.-11C>A upstream_gene_variant 0.4 ethambutol
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6005 p.Gly256Cys missense_variant 0.27
gyrB 6117 p.Trp293Leu missense_variant 0.22
gyrB 6139 c.900G>T synonymous_variant 0.33
gyrB 6175 p.Glu312Asp missense_variant 0.25
gyrB 7156 p.Asp639Glu missense_variant 0.2
gyrA 7296 c.-6G>T upstream_gene_variant 0.22
gyrA 7321 p.Pro7Gln missense_variant 0.2
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7521 p.Ala74Thr missense_variant 0.22
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7973 c.672A>G synonymous_variant 0.13
gyrA 8333 p.Asn344Lys missense_variant 0.18
gyrA 8689 p.Ala463Asp missense_variant 0.29
gyrA 8694 p.Leu465Met missense_variant 0.29
gyrA 9183 p.Arg628Ser missense_variant 0.22
gyrA 9192 p.Leu631Met missense_variant 0.22
gyrA 9286 p.Ala662Glu missense_variant 0.25
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9356 c.2055G>T synonymous_variant 0.25
gyrA 9513 p.Glu738* stop_gained 0.4
fgd1 490738 c.-45C>T upstream_gene_variant 0.29
fgd1 491037 c.255C>A synonymous_variant 0.2
fgd1 491422 p.Gly214Cys missense_variant 0.4
fgd1 491719 p.Pro313Thr missense_variant 0.29
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575379 p.Gly11Val missense_variant 0.29
mshA 575907 p.Ala187Val missense_variant 1.0
mshA 575917 c.570C>T synonymous_variant 0.5
mshA 576101 c.754C>A synonymous_variant 0.25
mshA 576148 c.801G>T synonymous_variant 0.33
mshA 576228 p.Arg294Leu missense_variant 0.25
mshA 576450 p.Pro368Gln missense_variant 0.4
ccsA 619750 c.-141C>A upstream_gene_variant 0.18
ccsA 620000 p.Ala37Asp missense_variant 0.33
ccsA 620233 p.Asn115Tyr missense_variant 0.4
ccsA 620625 p.Ile245Met missense_variant 1.0
ccsA 620678 p.Pro263His missense_variant 0.5
ccsA 620767 p.Ala293Thr missense_variant 0.33
ccsA 620824 p.Leu312Met missense_variant 0.4
rpoB 759889 p.Gly28Val missense_variant 0.22
rpoB 760011 p.Ala69Thr missense_variant 0.25
rpoB 760124 p.Phe106Leu missense_variant 0.22
rpoB 760165 p.Asp120Val missense_variant 0.17
rpoB 760330 p.Arg175Leu missense_variant 0.22
rpoB 760768 p.Pro321His missense_variant 0.22
rpoB 760935 p.Glu377* stop_gained 0.29
rpoB 761031 p.Gln409Lys missense_variant 0.25
rpoB 761184 p.Glu460Lys missense_variant 0.29
rpoB 761372 c.1566C>A synonymous_variant 0.67
rpoB 761419 p.Ala538Asp missense_variant 0.67
rpoB 761516 c.1710G>T synonymous_variant 0.5
rpoB 761636 c.1830G>T synonymous_variant 0.29
rpoB 761872 p.Arg689Gln missense_variant 0.33
rpoB 762168 p.Ala788Ser missense_variant 0.2
rpoB 762539 p.Leu911Phe missense_variant 0.25
rpoB 762549 p.Gly915Cys missense_variant 0.29
rpoB 762691 p.Pro962Gln missense_variant 0.25
rpoC 762698 c.-672C>A upstream_gene_variant 0.25
rpoB 762881 p.Met1025Ile missense_variant 0.25
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764030 p.Asp221Tyr missense_variant 0.23
rpoC 764233 p.Lys288Asn missense_variant 0.18
rpoC 764654 p.Val429Phe missense_variant 0.2
rpoC 764802 p.Arg478Leu missense_variant 0.29
rpoC 765345 p.Gly659Val missense_variant 0.25
rpoC 765521 p.Asp718Tyr missense_variant 0.22
rpoC 766177 c.2808C>A synonymous_variant 0.2
rpoC 766249 c.2880C>A synonymous_variant 0.25
rpoC 766737 p.Arg1123Gln missense_variant 0.4
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775862 c.2619G>T synonymous_variant 0.2
mmpL5 776066 c.2415C>A synonymous_variant 0.4
mmpL5 776089 p.Val798Ile missense_variant 0.5
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776136 p.Ser782Tyr missense_variant 0.25
mmpL5 776145 p.Ala779Asp missense_variant 0.29
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 776445 p.Ala679Val missense_variant 0.18
mmpL5 776520 p.Ser654Ile missense_variant 0.17
mmpL5 777024 p.Arg486Leu missense_variant 0.18
mmpL5 777032 c.1449C>A synonymous_variant 0.18
mmpL5 777118 p.Asp455Tyr missense_variant 0.25
mmpL5 777434 c.1047C>A synonymous_variant 0.25
mmpL5 777705 p.Ser259* stop_gained 0.4
mmpL5 777752 c.729C>A synonymous_variant 0.33
mmpL5 777761 c.720G>A synonymous_variant 0.33
mmpL5 777795 p.Ser229* stop_gained 0.3
mmpL5 777807 p.Ser225* stop_gained 0.22
mmpL5 777821 c.660G>A synonymous_variant 0.2
mmpL5 777880 p.Asp201Tyr missense_variant 0.22
mmpL5 777891 p.Gln197Leu missense_variant 0.2
mmpR5 778373 c.-617G>T upstream_gene_variant 0.29
mmpS5 778554 p.Val118Ile missense_variant 0.29
mmpL5 778558 c.-78C>A upstream_gene_variant 0.29
mmpR5 779006 p.Gly6Val missense_variant 0.2
mmpS5 779515 c.-610C>A upstream_gene_variant 0.29
mmpS5 779568 c.-663C>A upstream_gene_variant 0.17
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
mmpS5 779625 c.-720G>T upstream_gene_variant 0.2
mmpS5 779676 c.-771C>A upstream_gene_variant 0.33
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781599 p.Asp14Tyr missense_variant 0.33
rplC 800651 c.-158G>T upstream_gene_variant 0.2
rplC 800775 c.-34G>T upstream_gene_variant 0.25
rplC 801223 p.His139Asn missense_variant 0.29
rplC 801387 c.579G>T synonymous_variant 0.38
rplC 801426 c.618C>A synonymous_variant 0.2
fbiC 1302956 p.Ser9Tyr missense_variant 0.5
fbiC 1303114 p.Ala62Ser missense_variant 0.2
fbiC 1303154 p.Arg75Leu missense_variant 0.18
fbiC 1303170 c.240C>A synonymous_variant 0.22
fbiC 1303627 p.Ser233Gly missense_variant 0.18
fbiC 1303942 p.Val338Leu missense_variant 0.29
fbiC 1304013 c.1083G>T synonymous_variant 0.4
fbiC 1304225 p.Gly432Asp missense_variant 0.17
fbiC 1304275 p.Leu449Met missense_variant 0.22
fbiC 1304382 c.1452G>T synonymous_variant 0.2
fbiC 1304675 p.Gly582Val missense_variant 0.29
fbiC 1304807 p.Pro626His missense_variant 0.4
fbiC 1305222 c.2292C>A synonymous_variant 0.29
fbiC 1305285 p.Gln785His missense_variant 0.22
Rv1258c 1406094 p.Gly416Val missense_variant 0.25
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
Rv1258c 1406963 c.378G>T synonymous_variant 0.4
Rv1258c 1407329 p.Ser4Arg missense_variant 0.2
Rv1258c 1407354 c.-14C>A upstream_gene_variant 0.22
Rv1258c 1407410 c.-70C>A upstream_gene_variant 0.33
embR 1416240 p.Arg370Ser missense_variant 0.25
embR 1416314 p.Arg345Leu missense_variant 0.29
embR 1416321 p.Asp343Tyr missense_variant 0.29
embR 1416554 p.Ser265Tyr missense_variant 0.25
embR 1416708 p.Ala214Ser missense_variant 0.29
embR 1416815 p.Ala178Glu missense_variant 0.33
embR 1416934 c.414G>A synonymous_variant 0.33
embR 1417138 c.210G>T synonymous_variant 0.4
embR 1417212 p.Arg46Ser missense_variant 0.2
embR 1417216 c.132C>A synonymous_variant 0.22
embR 1417228 c.120C>A synonymous_variant 0.2
embR 1417421 c.-74G>T upstream_gene_variant 0.5
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472049 n.204G>T non_coding_transcript_exon_variant 0.4
rrs 1472098 n.253G>T non_coding_transcript_exon_variant 0.25
rrs 1472190 n.345G>T non_coding_transcript_exon_variant 0.22
rrs 1472270 n.425T>C non_coding_transcript_exon_variant 0.18
rrs 1472568 n.723C>T non_coding_transcript_exon_variant 0.67
rrl 1473435 n.-223C>A upstream_gene_variant 0.25
rrl 1473525 n.-133C>A upstream_gene_variant 0.25
rrl 1474198 n.541G>T non_coding_transcript_exon_variant 0.33
rrl 1474277 n.620C>A non_coding_transcript_exon_variant 0.33
rrl 1474470 n.813G>T non_coding_transcript_exon_variant 0.5
rrl 1474566 n.909G>T non_coding_transcript_exon_variant 0.5
rrl 1474827 n.1170C>A non_coding_transcript_exon_variant 0.5
rrl 1475186 n.1529C>A non_coding_transcript_exon_variant 0.67
rrl 1475396 n.1739C>A non_coding_transcript_exon_variant 0.4
rrl 1475400 n.1743C>A non_coding_transcript_exon_variant 0.6
fabG1 1673411 c.-29C>T upstream_gene_variant 0.4
fabG1 1673489 p.Ser17* stop_gained 0.33
fabG1 1673501 p.Thr21Asn missense_variant 0.33
fabG1 1673858 p.Ser140* stop_gained 0.29
fabG1 1673971 p.Ala178Ser missense_variant 0.17
inhA 1674222 c.21C>A synonymous_variant 0.33
inhA 1674276 c.75C>A synonymous_variant 0.22
inhA 1674364 p.Pro55Ser missense_variant 0.33
inhA 1674373 p.Ala58Ser missense_variant 0.22
inhA 1674414 c.213G>T synonymous_variant 0.22
inhA 1674454 p.Gly85Cys missense_variant 0.2
inhA 1674551 p.Ser117Tyr missense_variant 0.3
inhA 1674763 p.Leu188Ile missense_variant 0.23
inhA 1674775 p.Gly192Cys missense_variant 0.15
rpsA 1833424 c.-118C>A upstream_gene_variant 0.22
rpsA 1833658 c.117C>A synonymous_variant 0.25
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834397 p.His286Asn missense_variant 0.33
rpsA 1834499 p.Leu320Met missense_variant 0.4
rpsA 1834741 c.1200C>A synonymous_variant 0.33
tlyA 1917771 c.-169G>T upstream_gene_variant 0.29
tlyA 1917813 c.-127C>A upstream_gene_variant 0.2
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918080 c.141C>A synonymous_variant 0.29
tlyA 1918180 p.Val81Met missense_variant 0.4
tlyA 1918287 c.348C>A synonymous_variant 0.2
ndh 2101655 p.Ser463Ile missense_variant 0.25
ndh 2101880 p.Ser388Ile missense_variant 0.17
ndh 2102065 c.978G>A synonymous_variant 0.25
ndh 2102981 p.Gly21Val missense_variant 0.25
katG 2154037 p.Ser692Ile missense_variant 0.18
katG 2154417 c.1695G>T synonymous_variant 0.22
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2154804 c.1308G>A synonymous_variant 0.2
katG 2154842 p.Ala424Ser missense_variant 0.2
katG 2155310 p.Gly268Cys missense_variant 0.29
katG 2155495 p.Gly206Val missense_variant 0.22
katG 2155656 p.Lys152Asn missense_variant 0.2
katG 2155659 c.453C>A synonymous_variant 0.18
katG 2155863 c.249G>T synonymous_variant 0.25
katG 2155871 p.Glu81* stop_gained 0.25
katG 2155877 p.Asp79Tyr missense_variant 0.25
katG 2156220 c.-109G>T upstream_gene_variant 0.25
katG 2156235 c.-124G>T upstream_gene_variant 0.25
PPE35 2167712 c.2901C>A synonymous_variant 0.3
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2167954 p.Tyr887His missense_variant 0.13
PPE35 2168045 p.Leu856Phe missense_variant 0.29
PPE35 2168084 p.Glu843Asp missense_variant 0.22
PPE35 2168354 c.2259G>T synonymous_variant 0.67
PPE35 2169751 p.Gly288* stop_gained 0.43
PPE35 2169964 p.Leu217Ile missense_variant 0.29
PPE35 2170018 p.Ala199Ser missense_variant 0.33
PPE35 2170025 c.588G>T synonymous_variant 0.33
PPE35 2170032 p.Gly194Val missense_variant 0.33
PPE35 2170210 p.Ala135Thr missense_variant 0.2
Rv1979c 2221755 c.1410C>A synonymous_variant 0.23
Rv1979c 2222022 c.1143C>A synonymous_variant 0.2
Rv1979c 2222209 p.Ala319Asp missense_variant 0.27
Rv1979c 2222334 c.831C>A synonymous_variant 0.25
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2288728 p.Leu172Met missense_variant 0.18
pncA 2289221 c.21C>A synonymous_variant 0.25
pncA 2289527 c.-286C>A upstream_gene_variant 0.25
pncA 2289563 c.-322G>T upstream_gene_variant 0.22
pncA 2290222 c.-981C>A upstream_gene_variant 0.22
kasA 2517977 c.-138C>T upstream_gene_variant 0.22
kasA 2518167 p.Ala18Asp missense_variant 0.18
kasA 2518413 p.Ser100Ile missense_variant 0.4
kasA 2518424 p.Asp104Tyr missense_variant 0.4
kasA 2518467 p.Gly118Val missense_variant 0.4
kasA 2519158 c.1044C>T synonymous_variant 0.25
eis 2714179 p.Arg385Leu missense_variant 0.22
eis 2714308 p.Pro342Gln missense_variant 0.43
eis 2714411 p.Arg308Ser missense_variant 0.29
eis 2714459 p.Asp292Tyr missense_variant 0.29
eis 2714546 p.Glu263* stop_gained 0.3
eis 2714668 p.Gly222Val missense_variant 0.18
eis 2715400 c.-68C>A upstream_gene_variant 0.25
eis 2715495 c.-163G>T upstream_gene_variant 0.22
eis 2715585 c.-253C>A upstream_gene_variant 0.29
ahpC 2726084 c.-109C>A upstream_gene_variant 0.22
ahpC 2726316 p.Glu42* stop_gained 0.2
ahpC 2726586 p.Asp132Tyr missense_variant 0.22
folC 2747731 c.-133C>A upstream_gene_variant 0.25
folC 2747779 c.-181G>A upstream_gene_variant 0.25
pepQ 2859324 p.Phe365Leu missense_variant 0.29
pepQ 2859477 c.942T>C synonymous_variant 0.29
pepQ 2859928 p.Arg164Leu missense_variant 0.29
pepQ 2860160 p.Ala87Ser missense_variant 0.33
pepQ 2860181 p.Gly80Trp missense_variant 0.25
pepQ 2860484 c.-66G>A upstream_gene_variant 0.67
ribD 2986654 c.-185C>A upstream_gene_variant 0.2
ribD 2986668 c.-171C>A upstream_gene_variant 0.2
ribD 2987292 p.Thr152Ala missense_variant 0.15
ribD 2987375 c.537G>T synonymous_variant 0.2
Rv2752c 3064584 c.1608G>T synonymous_variant 0.29
Rv2752c 3064755 c.1437C>A synonymous_variant 0.33
Rv2752c 3064773 c.1419C>A synonymous_variant 0.33
Rv2752c 3064786 p.Ser469* stop_gained 0.29
Rv2752c 3064911 c.1281C>A synonymous_variant 0.36
Rv2752c 3065290 p.Val301Ala missense_variant 0.12
Rv2752c 3065413 p.Ser260* stop_gained 0.22
Rv2752c 3065420 c.772C>A synonymous_variant 0.22
Rv2752c 3066282 c.-91G>T upstream_gene_variant 0.22
Rv2752c 3067083 c.-892C>A upstream_gene_variant 0.25
Rv2752c 3067166 c.-975G>A upstream_gene_variant 0.2
Rv2752c 3067182 c.-991C>A upstream_gene_variant 0.27
thyX 3067310 c.636C>A synonymous_variant 0.2
thyX 3067408 p.Glu180* stop_gained 0.25
thyX 3067468 p.Ala160Ser missense_variant 1.0
thyX 3067955 c.-10G>T upstream_gene_variant 0.25
thyX 3067990 c.-45C>T upstream_gene_variant 0.2
thyX 3068046 c.-101G>T upstream_gene_variant 0.22
thyA 3073860 c.612C>A synonymous_variant 0.2
thyA 3074260 p.Trp71Leu missense_variant 0.2
thyA 3074337 c.135C>A synonymous_variant 0.2
thyA 3074438 p.Leu12Phe missense_variant 0.25
thyA 3074523 c.-52G>T upstream_gene_variant 0.25
thyA 3074536 c.-65G>T upstream_gene_variant 0.25
ald 3086650 c.-170C>A upstream_gene_variant 0.33
ald 3086731 c.-89A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086879 c.60G>T synonymous_variant 0.29
ald 3087123 p.Ala102Thr missense_variant 0.4
ald 3087286 p.Arg156Leu missense_variant 0.25
ald 3087322 p.Pro168Gln missense_variant 0.29
ald 3087544 p.Pro242Gln missense_variant 0.2
ald 3087874 p.Ser352Tyr missense_variant 0.33
fbiD 3339423 c.306G>T synonymous_variant 0.33
fbiD 3339735 c.618G>T synonymous_variant 0.29
Rv3083 3448794 p.Lys97Asn missense_variant 0.29
Rv3083 3448809 c.306G>T synonymous_variant 0.29
Rv3083 3449032 p.Gly177Cys missense_variant 0.33
Rv3083 3449207 p.Pro235Gln missense_variant 0.33
Rv3083 3449454 c.951G>T synonymous_variant 0.67
Rv3083 3449518 p.Ala339Ser missense_variant 0.67
Rv3083 3449554 p.Gln351Lys missense_variant 1.0
Rv3083 3449776 p.Asp425Asn missense_variant 0.29
fprA 3473833 c.-174G>T upstream_gene_variant 0.33
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474255 c.249C>A synonymous_variant 0.33
fprA 3474279 c.273C>A synonymous_variant 0.22
fprA 3474660 c.654C>A synonymous_variant 0.5
fprA 3475059 p.Ser351Arg missense_variant 0.4
fprA 3475064 p.Asn353Ser missense_variant 0.33
fprA 3475104 c.1098G>T synonymous_variant 0.4
fprA 3475294 p.Glu430* stop_gained 0.22
whiB7 3568574 p.Leu36Ile missense_variant 0.18
whiB7 3568716 c.-37G>T upstream_gene_variant 0.27
Rv3236c 3612450 p.Leu223Met missense_variant 0.2
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
Rv3236c 3612946 p.Phe57Leu missense_variant 0.22
Rv3236c 3613043 p.Ala25Glu missense_variant 0.22
fbiA 3640522 c.-21C>A upstream_gene_variant 0.33
fbiB 3640554 c.-981C>A upstream_gene_variant 0.18
fbiB 3640665 c.-870G>T upstream_gene_variant 0.3
fbiA 3640932 p.Glu130Asp missense_variant 0.33
fbiB 3641325 c.-210G>A upstream_gene_variant 0.5
fbiB 3641475 c.-60C>T upstream_gene_variant 0.5
fbiB 3641737 p.Glu68Val missense_variant 0.67
fbiB 3642223 p.Arg230Leu missense_variant 0.21
fbiB 3642484 p.Trp317Leu missense_variant 0.22
fbiB 3642490 p.Ser319Tyr missense_variant 0.25
alr 3840420 p.Arg334Leu missense_variant 0.25
alr 3840423 p.Arg333Ile missense_variant 0.25
alr 3840451 p.Gly324Trp missense_variant 0.4
alr 3840530 c.891C>T synonymous_variant 0.2
alr 3840535 p.Gly296Trp missense_variant 0.2
alr 3840619 p.Asp268Tyr missense_variant 0.18
alr 3840673 p.Leu250Met missense_variant 0.2
alr 3840790 p.Gln211Lys missense_variant 0.22
alr 3841187 c.234C>A synonymous_variant 0.25
alr 3841194 p.Arg76Leu missense_variant 0.25
alr 3841297 p.Leu42Met missense_variant 0.2
alr 3841313 c.108C>A synonymous_variant 0.22
alr 3841366 p.Gly19Cys missense_variant 0.25
alr 3841371 p.Gly17Val missense_variant 0.25
rpoA 3877620 p.Glu296Asp missense_variant 0.22
rpoA 3877665 c.843C>A synonymous_variant 0.27
rpoA 3877801 p.Pro236Gln missense_variant 0.22
rpoA 3877821 c.687C>A synonymous_variant 0.2
rpoA 3878088 c.420C>A synonymous_variant 0.29
rpoA 3878172 c.336G>T synonymous_variant 0.25
rpoA 3878416 p.Gly31Asp missense_variant 0.25
rpoA 3878463 c.45C>A synonymous_variant 0.2
ddn 3986758 c.-86G>T upstream_gene_variant 0.22
ddn 3987200 c.357C>T synonymous_variant 0.33
clpC1 4038226 p.Pro827Ser missense_variant 0.5
clpC1 4038317 c.2388G>T synonymous_variant 0.4
clpC1 4038933 p.Ala591Glu missense_variant 0.4
clpC1 4039028 p.Lys559Asn missense_variant 0.4
clpC1 4039294 p.Gly471Cys missense_variant 0.18
clpC1 4039541 c.1164C>A synonymous_variant 0.22
clpC1 4039682 c.1023C>A synonymous_variant 0.29
clpC1 4039761 p.Gly315Val missense_variant 0.33
clpC1 4039763 c.942C>T synonymous_variant 0.33
clpC1 4039996 p.Glu237* stop_gained 0.22
clpC1 4040880 c.-176G>T upstream_gene_variant 0.29
panD 4044048 p.Leu78Phe missense_variant 0.4
panD 4044069 c.213C>A synonymous_variant 0.4
panD 4044224 p.Leu20Met missense_variant 0.5
panD 4044326 c.-45C>A upstream_gene_variant 0.22
panD 4044434 c.-153G>T upstream_gene_variant 0.22
embC 4239671 c.-192C>A upstream_gene_variant 0.22
embC 4239758 c.-105C>A upstream_gene_variant 0.5
embC 4240093 c.231C>T synonymous_variant 0.2
embC 4240139 p.Gly93* stop_gained 0.18
embC 4240847 p.Asp329Tyr missense_variant 0.29
embC 4241106 p.Arg415Leu missense_variant 0.33
embC 4241392 c.1530G>T synonymous_variant 0.2
embC 4241514 p.Ser551* stop_gained 0.33
embC 4241575 c.1713C>A synonymous_variant 0.4
embC 4241764 p.Phe634Leu missense_variant 0.29
embC 4241773 c.1911C>A synonymous_variant 0.29
embC 4241853 p.Ala664Glu missense_variant 0.22
embC 4241937 p.Arg692Met missense_variant 0.15
embC 4241980 c.2118C>A synonymous_variant 0.44
embC 4242354 p.Gly831Val missense_variant 0.5
embC 4242572 p.Glu904* stop_gained 0.22
embC 4242588 p.Gly909Val missense_variant 0.22
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4243565 p.Gln111His missense_variant 0.33
embA 4243580 c.348G>T synonymous_variant 0.33
embA 4243770 p.Gly180* stop_gained 0.22
embA 4243800 p.Asp190Tyr missense_variant 0.22
embA 4243844 c.612G>A synonymous_variant 0.2
embA 4243862 c.630C>A synonymous_variant 0.25
embA 4243866 p.Leu212Met missense_variant 0.22
embA 4245056 c.1824C>A synonymous_variant 0.33
embA 4245585 p.Pro785Thr missense_variant 0.2
embA 4245708 p.Ala826Ser missense_variant 0.18
embA 4245799 p.Trp856Leu missense_variant 0.22
embA 4245847 p.Ser872Tyr missense_variant 0.29
embB 4245851 c.-663G>A upstream_gene_variant 0.29
embA 4245868 p.Ser879Tyr missense_variant 0.5
embB 4245899 c.-615C>A upstream_gene_variant 0.33
embB 4245908 c.-606G>T upstream_gene_variant 0.5
embA 4245958 p.Gly909Val missense_variant 0.4
embB 4246307 c.-207G>T upstream_gene_variant 0.5
embA 4246311 p.Gly1027Cys missense_variant 0.33
embA 4246428 p.Ala1066Thr missense_variant 0.29
embB 4246682 p.Asp57Tyr missense_variant 0.25
embB 4246762 c.249G>T synonymous_variant 0.29
embB 4246954 c.441C>T synonymous_variant 0.29
embB 4246960 p.Glu149Asp missense_variant 0.29
embB 4247009 p.Asp166Tyr missense_variant 0.29
embB 4247027 p.Leu172Met missense_variant 0.25
embB 4247398 c.885G>T synonymous_variant 0.25
embB 4247408 p.Asp299Tyr missense_variant 0.25
embB 4247428 c.915C>A synonymous_variant 0.29
embB 4247726 p.Glu405* stop_gained 0.29
embB 4248076 p.Glu521Asp missense_variant 0.29
embB 4248460 c.1947C>A synonymous_variant 0.25
embB 4248493 p.Met660Ile missense_variant 0.22
embB 4248571 c.2058G>T synonymous_variant 0.22
embB 4248976 c.2463G>T synonymous_variant 0.21
embB 4249340 p.Ala943Thr missense_variant 0.22
embB 4249378 c.2865G>T synonymous_variant 0.2
embB 4249489 p.Leu992Phe missense_variant 0.29
embB 4249510 c.2997G>T synonymous_variant 0.29
embB 4249647 p.Arg1045Leu missense_variant 0.4
embB 4249679 p.Asp1056Tyr missense_variant 0.25
embB 4249770 p.Ser1086Ile missense_variant 0.25
aftB 4267080 p.Arg586Leu missense_variant 0.5
aftB 4267123 c.1714C>A synonymous_variant 0.5
aftB 4267274 c.1563G>T synonymous_variant 0.22
aftB 4267403 p.Pro478Gln missense_variant 0.18
aftB 4267583 c.1254C>A synonymous_variant 0.33
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4267670 c.1167G>T synonymous_variant 0.5
aftB 4268097 p.Gly247Asp missense_variant 0.2
aftB 4268231 c.606C>T synonymous_variant 0.4
aftB 4268251 p.Ala196Ser missense_variant 0.67
aftB 4268543 c.294C>A synonymous_variant 0.67
aftB 4268831 c.6C>T synonymous_variant 0.29
ubiA 4269029 p.Gly269Cys missense_variant 0.25
ubiA 4269367 p.Ala156Glu missense_variant 0.25
ubiA 4269397 p.Ala146Glu missense_variant 0.33
ubiA 4269672 p.Lys54Asn missense_variant 0.2
ubiA 4269710 p.Gly42Cys missense_variant 0.18
aftB 4269711 c.-875C>T upstream_gene_variant 0.17
aftB 4269780 c.-944C>A upstream_gene_variant 0.25
aftB 4269792 c.-956C>A upstream_gene_variant 0.29
ethA 4326181 p.Phe431Leu missense_variant 0.21
ethA 4326350 p.Ser375Phe missense_variant 0.17
ethA 4326714 p.Gln254Lys missense_variant 0.2
ethR 4326868 c.-681G>T upstream_gene_variant 0.38
ethR 4327159 c.-390G>A upstream_gene_variant 0.29
ethA 4327191 p.Asp95Tyr missense_variant 0.2
ethR 4327390 c.-159C>A upstream_gene_variant 0.33
ethR 4327601 p.Ala18Val missense_variant 0.18
ethR 4327862 p.Thr105Ile missense_variant 0.2
ethA 4328064 c.-591G>T upstream_gene_variant 0.22
whiB6 4338371 p.Thr51Pro missense_variant 1.0
whiB6 4338464 p.Asp20Tyr missense_variant 0.18
whiB6 4338489 c.33C>A synonymous_variant 0.17
whiB6 4338585 c.-64G>T upstream_gene_variant 0.25
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407531 c.672G>T synonymous_variant 0.22
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407813 c.390C>A synonymous_variant 0.17
gid 4407927 p.Glu92Asp missense_variant 1.0
gid 4408091 p.Pro38Thr missense_variant 0.14