TB-Profiler result

Run: ERR7737726
Summary

Run ID: ERR7737726

Sample name:

Date: 02-04-2023 05:28:10

Number of reads: 127954

Percentage reads mapped: 99.59

Strain:

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage3.1.1 East-African-Indian CAS1-Kili RD750 0.12
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472751 n.906A>G non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288887 p.Trp119Arg missense_variant 1.0 pyrazinamide
embB 4248003 p.Gln497Arg missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764843 p.Ala492Pro missense_variant 0.29
rpoC 765519 p.Lys717Thr missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781437 c.-123G>A upstream_gene_variant 0.67
fbiC 1302877 c.-54T>G upstream_gene_variant 0.5
fbiC 1302901 c.-30G>A upstream_gene_variant 0.4
Rv1258c 1406366 p.Tyr325* stop_gained 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170461 p.Gly51Glu missense_variant 1.0
Rv1979c 2222880 c.285T>A synonymous_variant 0.67
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289047 c.195C>T synonymous_variant 1.0
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0
pepQ 2860559 c.-141G>A upstream_gene_variant 0.5
Rv2752c 3065848 c.343_344insT frameshift_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339676 p.Cys187Gly missense_variant 0.4
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3640618 p.Gly26Ser missense_variant 0.4
fbiB 3642798 p.Gly422Ser missense_variant 0.4
embC 4240172 p.Val104Met missense_variant 1.0
embC 4241562 p.Arg567His missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4247142 p.Phe210Tyr missense_variant 0.25
embB 4248061 c.1548G>A synonymous_variant 0.4
embB 4248062 p.Ala517Thr missense_variant 0.4
embB 4249780 p.Trp1089* stop_gained 0.33
aftB 4268717 c.120C>T synonymous_variant 0.33
whiB6 4338268 p.Gly85Ala missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
ethR 4327269 c.-279_*1678del transcript_ablation 1.0