TB-Profiler result

Run: ERR7764424
Summary

Run ID: ERR7764424

Sample name:

Date: 02-04-2023 05:47:15

Number of reads: 1323120

Percentage reads mapped: 99.47

Strain: lineage4.1.1.3

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpsL 781822 p.Lys88Arg missense_variant 1.0 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 490756 c.-27T>G upstream_gene_variant 0.27
mshA 576456 p.Val370Gly missense_variant 0.4
mshA 576468 p.Val374Gly missense_variant 0.43
mshA 576483 p.Val379Gly missense_variant 0.33
mshA 576489 p.Val381Gly missense_variant 0.6
mshA 576618 p.His424Pro missense_variant 0.33
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1476058 n.2401T>G non_coding_transcript_exon_variant 0.21
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2170065 p.Ala183Gly missense_variant 0.33
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pepQ 2860159 p.Ala87Gly missense_variant 0.38
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339734 p.Ala206Gly missense_variant 0.6
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474212 p.Lys69Thr missense_variant 0.23
Rv3236c 3612818 p.Asn100Thr missense_variant 0.11
rpoA 3878514 c.-7A>G upstream_gene_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4243681 p.Ala150Val missense_variant 1.0
embB 4246584 p.Arg24Pro missense_variant 0.22
embB 4247015 p.Ser168Gly missense_variant 0.2
embB 4248328 c.1815G>C synonymous_variant 0.14
embB 4249408 c.2895G>A synonymous_variant 1.0
aftB 4268619 p.Val73Gly missense_variant 0.46
aftB 4268623 p.Trp72Gly missense_variant 0.27
whiB6 4338200 p.Asp108His missense_variant 0.22
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408295 c.-93G>A upstream_gene_variant 1.0