TB-Profiler result

Run: ERR8774177
Summary

Run ID: ERR8774177

Sample name:

Date: 02-04-2023 08:24:49

Number of reads: 207454

Percentage reads mapped: 99.54

Strain: lineage4.3.4.2.1

Drug-resistance: RR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.4.2 Euro-American (LAM) LAM1;LAM4;LAM11 RD174 1.0
lineage4.3.4.2.1 Euro-American (LAM) LAM11 RD174 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761095 p.Leu430Pro missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5323 c.84A>G synonymous_variant 0.29
gyrB 6140 p.Val301Leu missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
ccsA 620529 c.639G>T synonymous_variant 0.29
rpoB 761657 c.1851C>A synonymous_variant 0.4
rpoB 762313 p.Gly836Val missense_variant 0.25
rpoC 762959 c.-411G>T upstream_gene_variant 0.18
rpoC 764995 c.1626C>G synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775800 p.Ser894* stop_gained 0.22
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
fabG1 1673603 p.Leu55Pro missense_variant 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918068 c.129C>T synonymous_variant 0.22
katG 2155383 c.729C>A synonymous_variant 0.33
PPE35 2169980 c.633C>T synonymous_variant 0.22
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
folC 2746929 p.Pro224Thr missense_variant 0.29
folC 2747537 p.Pro21Leu missense_variant 0.29
pepQ 2859373 p.Pro349Leu missense_variant 0.25
thyX 3067335 p.Ala204Asp missense_variant 0.3
thyX 3067418 c.528C>A synonymous_variant 0.2
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087893 p.Asp358Glu missense_variant 0.18
Rv3083 3449160 c.657G>A synonymous_variant 0.2
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0
Rv3236c 3612793 c.324C>A synonymous_variant 0.29
fbiB 3641642 c.108G>T synonymous_variant 0.33
alr 3840719 c.702A>G synonymous_variant 1.0
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4039152 p.Ile518Thr missense_variant 0.5
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244524 p.Pro431Gln missense_variant 0.15
embA 4245465 p.Pro745Thr missense_variant 0.22
aftB 4267742 c.1095G>T synonymous_variant 0.4
aftB 4269345 c.-509C>A upstream_gene_variant 0.5
ethA 4328398 c.-925C>A upstream_gene_variant 0.25
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0