TB-Profiler result

Run: ERR8774317
Summary

Run ID: ERR8774317

Sample name:

Date: 02-04-2023 08:27:06

Number of reads: 589736

Percentage reads mapped: 99.63

Strain: lineage4.6.2.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.2 Euro-American T;LAM RD726 0.99
lineage4.6.2.2 Euro-American (Cameroon) LAM10-CAM RD726 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoB 761537 c.1731C>A synonymous_variant 0.14
rpoB 762020 p.Glu738Asp missense_variant 0.17
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 778298 c.-692C>T upstream_gene_variant 1.0
mmpR5 779005 p.Gly6Arg missense_variant 0.17
mmpR5 779008 p.Val7Ile missense_variant 0.17
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303672 p.Ala248Ser missense_variant 0.22
Rv1258c 1406124 p.Ala406Glu missense_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2156487 c.-376G>T upstream_gene_variant 0.22
PPE35 2169053 c.1560T>C synonymous_variant 1.0
PPE35 2169059 c.1554G>A synonymous_variant 1.0
PPE35 2169063 p.Met517Thr missense_variant 1.0
PPE35 2169065 p.Ala516Thr missense_variant 1.0
PPE35 2169068 c.1545G>T synonymous_variant 1.0
PPE35 2170048 p.Leu189Val missense_variant 0.54
PPE35 2170053 p.Thr187Ser missense_variant 0.54
PPE35 2170332 p.Val94Glu missense_variant 0.2
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 0.92
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518606 c.492G>C synonymous_variant 0.17
kasA 2518609 p.Met165Ile missense_variant 0.17
eis 2715426 c.-94G>T upstream_gene_variant 1.0
Rv3083 3448567 p.His22Asp missense_variant 1.0
fprA 3473962 c.-45C>A upstream_gene_variant 0.22
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612760 c.357C>A synonymous_variant 0.15
fbiB 3641567 c.33C>A synonymous_variant 0.14
clpC1 4040245 p.Gly154Ser missense_variant 0.15
embC 4241740 c.1878G>T synonymous_variant 0.17
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246548 p.Pro12Gln missense_variant 0.2
embB 4246555 c.42G>C synonymous_variant 0.2
embB 4246556 p.Ala15Pro missense_variant 0.2
aftB 4267272 p.Lys522Arg missense_variant 1.0
aftB 4268342 c.495C>T synonymous_variant 0.17
ethA 4326191 p.Glu428Gly missense_variant 0.2
ethA 4326535 c.939G>T synonymous_variant 0.33
ethR 4326739 c.-810G>C upstream_gene_variant 1.0
ethA 4328004 c.-531C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0