TB-Profiler result

Run: ERR9030337
Summary

Run ID: ERR9030337

Sample name:

Date: 02-04-2023 09:25:35

Number of reads: 1651614

Percentage reads mapped: 99.95

Strain: lineage4.6.2.2

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.6 Euro-American T;LAM None 1.0
lineage4.6.2.2 Euro-American (Cameroon) LAM10-CAM RD726 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7581 p.Asp94Asn missense_variant 0.29 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7587 p.Leu96Met missense_variant 0.29
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 575184 c.-164G>A upstream_gene_variant 0.15
mshA 576044 p.Ala233Thr missense_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 778298 c.-692C>T upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2221746 c.1416_1418dupCCG disruptive_inframe_insertion 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 0.98
kasA 2518839 p.Ala242Gly missense_variant 0.2
folC 2747325 p.Arg92Cys missense_variant 0.12
Rv3083 3448567 p.His22Asp missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3878641 c.-135delG upstream_gene_variant 0.22
embA 4244213 c.981C>A synonymous_variant 0.29
embA 4244352 p.Pro374Thr missense_variant 0.33
embB 4246618 c.105G>T synonymous_variant 0.2
aftB 4267272 p.Lys522Arg missense_variant 1.0
ubiA 4269869 c.-36G>A upstream_gene_variant 0.29
ethR 4326739 c.-810G>C upstream_gene_variant 1.0
ethA 4328004 c.-531C>T upstream_gene_variant 1.0
ethA 4328397 c.-924G>A upstream_gene_variant 0.12
ethA 4328416 c.-943G>A upstream_gene_variant 0.14
whiB6 4338595 c.-75delG upstream_gene_variant 1.0