TB-Profiler result

Run: ERR9117752
Summary

Run ID: ERR9117752

Sample name:

Date: 02-04-2023 09:30:22

Number of reads: 952238

Percentage reads mapped: 99.05

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5487 p.Gly83Asp missense_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 575311 c.-37A>G upstream_gene_variant 0.11
rpoB 759615 c.-192A>C upstream_gene_variant 0.33
rpoC 762390 c.-980C>T upstream_gene_variant 0.11
rpoB 762829 p.Arg1008His missense_variant 0.12
rpoC 765745 c.2377delT frameshift_variant 0.22
rpoC 766891 c.3527delT frameshift_variant 0.11
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 778086 c.394delG frameshift_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1304060 p.Leu377Pro missense_variant 0.17
Rv1258c 1407055 c.285delG frameshift_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.4
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.4
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.4
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.4
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.29
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.29
rrl 1473508 n.-150A>C upstream_gene_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918054 p.Ala39Thr missense_variant 0.18
ndh 2102170 c.873G>A synonymous_variant 0.13
PPE35 2167955 c.2658A>C synonymous_variant 0.12
PPE35 2167965 p.Ala883Gly missense_variant 0.13
PPE35 2167967 c.2646A>C synonymous_variant 0.13
PPE35 2169947 p.Asn222Lys missense_variant 0.13
PPE35 2170115 c.498G>T synonymous_variant 0.11
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289328 c.-87T>A upstream_gene_variant 0.11
kasA 2518809 p.Lys232Arg missense_variant 0.14
kasA 2518864 c.750G>C synonymous_variant 0.13
kasA 2518879 c.765A>G synonymous_variant 0.12
kasA 2518882 c.768C>A synonymous_variant 0.13
kasA 2519155 c.1041C>A synonymous_variant 0.13
folC 2747524 c.75G>A synonymous_variant 0.11
pepQ 2860154 p.Glu89Gln missense_variant 0.11
pepQ 2860497 c.-79C>T upstream_gene_variant 0.1
Rv2752c 3064578 c.1614C>A synonymous_variant 1.0
ald 3087391 p.Gly191Asp missense_variant 0.18
fprA 3474280 p.Glu92* stop_gained 0.12
fprA 3474780 c.774C>T synonymous_variant 0.12
fbiA 3640680 p.Asn46Lys missense_variant 0.12
fbiB 3642079 p.Pro182Arg missense_variant 0.18
fbiB 3642277 p.Ala248Glu missense_variant 0.12
alr 3840483 p.Gly313Asp missense_variant 0.1
alr 3840890 c.531C>T synonymous_variant 0.11
embC 4241659 c.1797G>A synonymous_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 0.96
embA 4244494 p.Leu421Pro missense_variant 0.13
embA 4244760 p.Asn510Tyr missense_variant 0.12
embB 4247760 p.Tyr416Cys missense_variant 0.1
ethR 4327803 p.Met85Ile missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0