TB-Profiler result

Run: ERR9806750
Summary

Run ID: ERR9806750

Sample name:

Date: 21-05-2023 01:51:29

Number of reads: 152099

Percentage reads mapped: 97.6

Strain:

Drug-resistance: HR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid R inhA p.Ile21Val (0.67)
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 0.13
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
inhA 1674262 p.Ile21Val missense_variant 0.67 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8174 c.873C>G synonymous_variant 0.4
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 764244 p.Ala292Gly missense_variant 0.5
rpoC 764363 p.Gly332Ser missense_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779407 p.Arg140Trp missense_variant 0.67
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1416643 c.705G>A synonymous_variant 0.4
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.5
rrl 1473672 n.15G>T non_coding_transcript_exon_variant 0.22
rrl 1474300 n.643C>A non_coding_transcript_exon_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2156027 p.Pro29Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714426 p.Ala303Pro missense_variant 0.4
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448892 p.Thr130Ile missense_variant 0.5
fprA 3474284 c.280_315delTCCGAGCGCTACGACGCCGTGATCTACGCCGTCGGC conservative_inframe_deletion 1.0
rpoA 3878243 p.Glu89Gln missense_variant 1.0
embC 4240147 c.285C>T synonymous_variant 0.4
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249408 c.2895G>A synonymous_variant 1.0
aftB 4268045 c.792C>T synonymous_variant 0.4
aftB 4268802 p.Ala12Glu missense_variant 0.33
ethA 4327479 c.-6G>A upstream_gene_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0