TB-Profiler result

Run: SRR12619590
Summary

Run ID: SRR12619590

Sample name:

Date: 2024-04-15T07:51:03.636278

Number of reads: 55913085

Percentage reads mapped: 99.28

Median coverage: 1497.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
Rv0010c 13627 c.-69A>G upstream_gene_variant 0.18 isoniazid Uncertain significance
hadA 732359 c.435_439delTGCCG frameshift_variant 1.0 isoniazid Uncertain significance
rpoB 761349 p.Asp515Asn missense_variant 0.36 rifampicin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472767 n.925dupC non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473218 n.1373T>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
kasA 2518527 p.Ser138Tyr missense_variant 1.0 isoniazid
glpK 4139604 p.Pro51Leu missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin
streptomycin Uncertain significance
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance