Run ID: SRR13837619
Sample name:
Date: 2024-04-14T22:11:29.407519
Number of reads: 294314
Percentage reads mapped: 97.18
Median coverage: 10.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6667 | p.Gln476His | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7289 | c.-13_-12insT | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
rpoB | 760214 | p.Asn136Lys | missense_variant | 1.0 | rifampicin | |
Rv1129c | 1253228 | p.Asp436Ala | missense_variant | 1.0 | moxifloxacin | |
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
Rv1129c | 1253885 | p.Lys217Arg | missense_variant | 1.0 | moxifloxacin | |
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
rrs | 1471943 | n.98T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473370 | n.1525T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
fabG1 | 1673813 | p.Arg125Leu | missense_variant | 1.0 | ethionamide | |
isoniazid | ||||||
inhA | 1674784 | p.Arg195Gly | missense_variant | 1.0 | ethionamide | |
isoniazid | ||||||
bacA | 2064693 | p.Trp12Cys | missense_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
kasA | 2519223 | p.Thr370Ile | missense_variant | 1.0 | isoniazid | |
ahpC | 2726213 | c.21C>T | synonymous_variant | 1.0 | isoniazid | |
ribD | 2987016 | p.Gly60Arg | missense_variant | 1.0 | para-aminosalicylic_acid | |
Rv2680 | 2996618 | p.Trp172Arg | missense_variant | 1.0 | capreomycin | |
Rv2681 | 2997515 | c.777T>G | synonymous_variant | 1.0 | capreomycin | |
Rv2752c | 3066590 | c.-399A>G | upstream_gene_variant | 1.0 | ethambutol | |
moxifloxacin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
thyA | 3074595 | c.-124C>A | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
lpqB | 3624763 | p.Val50Leu | missense_variant | 1.0 | bedaquiline | |
rifampicin | ||||||
embC | 4242810 | p.Leu983Gln | missense_variant | 1.0 | ethambutol | |
gid | 4408480 | c.-278G>C | upstream_gene_variant | 1.0 | streptomycin |