TB-Profiler result

Run: SRR13837633
Summary

Run ID: SRR13837633

Sample name:

Date: 2024-04-15T14:53:58.159044

Number of reads: 293854

Percentage reads mapped: 98.01

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
Rv0565c 657052 p.Phe140Cys missense_variant 1.0 ethionamide
sigE 1364478 c.66C>T synonymous_variant 1.0 pyrazinamide
rpsA 1833851 p.Lys104Gln missense_variant 1.0 pyrazinamide
Rv1979c 2223241 c.-77C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
pncA 2289994 c.-753A>C upstream_gene_variant 1.0 pyrazinamide
kasA 2518301 p.His63Asp missense_variant 1.0 isoniazid
pepQ 2859859 p.Ala187Glu missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv3236c 3613541 c.-425C>A upstream_gene_variant 1.0 pyrazinamide
fbiB 3641723 c.189T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
embC 4241005 c.1143G>T synonymous_variant 1.0 ethambutol