TB-Profiler result

Run: SRR13837642
Summary

Run ID: SRR13837642

Sample name:

Date: 2025-02-11T09:51:03.115244

Number of reads: 297564

Percentage reads mapped: 97.23

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5540 p.Thr101Ser missense_variant 1.0 levofloxacin
moxifloxacin
nusG 734249 c.-5A>G upstream_gene_variant 1.0 rifampicin
rpoB 760558 c.753delC frameshift_variant 0.94 rifampicin
rpoB 762490 p.Val895Gly missense_variant 1.0 rifampicin
ndh 2101690 p.Glu451Asp missense_variant 1.0 isoniazid
delamanid
ethionamide
PPE35 2168961 p.Gly551Val missense_variant 1.0 pyrazinamide
Rv1979c 2222084 p.Leu361Ile missense_variant 1.0 bedaquiline
clofazimine
Rv1979c 2222431 p.Met245Arg missense_variant 1.0 bedaquiline
clofazimine
Rv1979c 2223625 c.-461C>A upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
ald 3087020 c.201C>T synonymous_variant 1.0 cycloserine
mtrB 3625191 p.Val475Leu missense_variant 1.0 rifampicin
bedaquiline
mtrB 3625358 p.Asn419Thr missense_variant 1.0 rifampicin
bedaquiline
mtrB 3625682 p.Leu311Gln missense_variant 1.0 rifampicin
bedaquiline
alr 3841157 c.264A>G synonymous_variant 1.0 cycloserine
embB 4247452 c.939C>T synonymous_variant 1.0 ethambutol