TB-Profiler result

Run: SRR13837649
Summary

Run ID: SRR13837649

Sample name:

Date: 2024-10-04T19:30:49.043163

Number of reads: 293856

Percentage reads mapped: 95.02

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 9490 p.Gly730Asp missense_variant 1.0 levofloxacin
moxifloxacin
Rv0010c 13883 c.-325T>A upstream_gene_variant 1.0 isoniazid
fgd1 491231 p.Phe150Tyr missense_variant 1.0 pretomanid
delamanid
clofazimine
rpsL 781503 c.-57T>C upstream_gene_variant 1.0 streptomycin
rplC 800381 c.-428A>G upstream_gene_variant 1.0 linezolid Uncertain significance
sigE 1364655 p.Met81Ile missense_variant 1.0 pyrazinamide
Rv1258c 1407463 c.-123G>C upstream_gene_variant 1.0 streptomycin
pyrazinamide
isoniazid
rrl 1474235 n.578G>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475139 n.1482C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476248 n.2591G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1476576 n.2919C>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
bacA 2063299 p.Trp477Leu missense_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
folC 2746788 p.Ala271Pro missense_variant 1.0 para-aminosalicylic_acid
thyX 3067214 p.Ser244Arg missense_variant 1.0 para-aminosalicylic_acid
fbiD 3339396 c.279C>T synonymous_variant 1.0 pretomanid
delamanid
clofazimine
rpoA 3878048 p.Ala154Ser missense_variant 1.0 rifampicin
panD 4044922 c.-641G>T upstream_gene_variant 1.0 pyrazinamide
ethA 4327097 p.Leu126His missense_variant 1.0 ethionamide
gid 4407792 c.411G>C synonymous_variant 1.0 streptomycin