TB-Profiler result

Run: SRR13837675
Summary

Run ID: SRR13837675

Sample name:

Date: 2024-04-16T08:16:13.988790

Number of reads: 293836

Percentage reads mapped: 100.0

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6715 c.1476C>T synonymous_variant 1.0 levofloxacin
moxifloxacin Not assoc w R - Interim
mshA 575693 p.Pro116Ala missense_variant 1.0 ethionamide
isoniazid
rpoB 759863 p.Gln19His missense_variant 1.0 rifampicin
rpoC 764516 p.Asp383Asn missense_variant 1.0 rifampicin
rpsL 781333 c.-227C>G upstream_gene_variant 1.0 streptomycin
Rv1979c 2221777 p.Ala463Val missense_variant 1.0 clofazimine
bedaquiline
ahpC 2726300 c.108C>A synonymous_variant 1.0 isoniazid
Rv2752c 3065523 c.669C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066039 c.153C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
lpqB 3623677 p.Val412Phe missense_variant 1.0 bedaquiline
rifampicin
alr 3841286 c.135T>A synonymous_variant 1.0 cycloserine
clpC1 4039368 p.Lys446Thr missense_variant 1.0 pyrazinamide
embC 4241777 p.Gly639Ser missense_variant 1.0 ethambutol