TB-Profiler result

Run: SRR13837677
Summary

Run ID: SRR13837677

Sample name:

Date: 2024-04-15T19:49:37.590487

Number of reads: 298658

Percentage reads mapped: 96.57

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6715 c.1476C>T synonymous_variant 1.0 levofloxacin
moxifloxacin Not assoc w R - Interim
rpoB 759863 p.Gln19His missense_variant 1.0 rifampicin
rpoB 760399 p.Val198Ala missense_variant 1.0 rifampicin
rpoC 766103 p.Arg912Gly missense_variant 1.0 rifampicin
ndh 2103185 c.-143A>C upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
PPE35 2170039 p.Ala192Thr missense_variant 1.0 pyrazinamide
kasA 2518793 p.Ser227Thr missense_variant 0.92 isoniazid
ahpC 2726300 c.108C>A synonymous_variant 1.0 isoniazid
folC 2747094 p.Asp169His missense_variant 0.91 para-aminosalicylic_acid
Rv2752c 3064936 p.Ser419* stop_gained 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065523 c.669C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066039 c.153C>T synonymous_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
lpqB 3623677 p.Val412Phe missense_variant 1.0 bedaquiline
rifampicin
embC 4241777 p.Gly639Ser missense_variant 0.92 ethambutol