TB-Profiler result

Run: SRR13837692
Summary

Run ID: SRR13837692

Sample name:

Date: 2024-03-25T21:42:09.551535

Number of reads: 293889

Percentage reads mapped: 96.02

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 9502 p.Arg734His missense_variant 1.0 levofloxacin
moxifloxacin
mmpL5 776185 p.Lys766Glu missense_variant 1.0 clofazimine
bedaquiline
mmpL5 779400 c.-920C>A upstream_gene_variant 1.0 clofazimine
bedaquiline
embR 1417986 c.-639T>A upstream_gene_variant 1.0 ethambutol
tlyA 1918063 p.Pro42Ala missense_variant 1.0 capreomycin
ndh 2102985 p.Ile20Val missense_variant 1.0 ethionamide
delamanid
isoniazid
katG 2155856 p.Thr86Ser missense_variant 1.0 isoniazid
Rv2752c 3065376 c.815delT frameshift_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066351 c.-160G>T upstream_gene_variant 1.0 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067731 p.Val72Ala missense_variant 1.0 para-aminosalicylic_acid
fbiD 3338949 c.-169_-168insT upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
Rv3083 3448707 c.204G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv3083 3449768 p.Thr422Lys missense_variant 1.0 ethionamide
fbiB 3641403 c.-132C>T upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
embC 4241864 p.Leu668Met missense_variant 1.0 ethambutol
gid 4408151 p.Leu18Val missense_variant 1.0 streptomycin