TB-Profiler result

Run: SRR13837695
Summary

Run ID: SRR13837695

Sample name:

Date: 2024-10-04T02:22:50.108056

Number of reads: 294847

Percentage reads mapped: 97.34

Median coverage: 10.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.1313_1314insT Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2154798 c.1313_1314insT frameshift_variant 1.0 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5906 p.Val223Leu missense_variant 1.0 levofloxacin
moxifloxacin
fgd1 490676 c.-107G>C upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
rpoB 760454 c.650delG frameshift_variant 0.94 rifampicin
rpsL 781409 c.-151T>A upstream_gene_variant 1.0 streptomycin
Rv1129c 1254452 p.Glu28Ala missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
fbiC 1302873 c.-58A>T upstream_gene_variant 1.0 pretomanid
delamanid
clofazimine
rrs 1471874 n.29A>C non_coding_transcript_exon_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064843 c.-115C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
katG 2154882 c.1230G>A synonymous_variant 1.0 isoniazid
katG 2155857 c.255C>A synonymous_variant 1.0 isoniazid
eis 2714922 c.411G>A synonymous_variant 1.0 kanamycin
amikacin
thyA 3074067 c.405C>G synonymous_variant 1.0 para-aminosalicylic_acid
lpqB 3624738 p.Ala58Val missense_variant 0.94 rifampicin
bedaquiline
mtrB 3625436 p.Ile393Asn missense_variant 1.0 rifampicin
bedaquiline
embA 4245071 c.1839G>A synonymous_variant 1.0 ethambutol