TB-Profiler

TB-Profiler result

Run: SRR13861557

This average coverage of the target regions is below the recommended 30x. Some mutations may not be detected due to low coverage.

Summary

Run ID: SRR13861557

Sample name:

Date: 2024-04-16T10:51:18.052026

Number of reads: 214720

Percentage reads mapped: 21.49

Median coverage: 7.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs
fbiC	1304512	p.Val528Ile	missense_variant	1.0	clofazimine
					pretomanid
					delamanid
katG	2156840	c.-729C>T	upstream_gene_variant	1.0	isoniazid
Rv1979c	2222085	c.1080G>C	synonymous_variant	1.0	clofazimine
Rv1979c	2222085	c.1080G>C	synonymous_variant	1.0	bedaquiline
embC	4241259	c.1397_1398insT	frameshift_variant	1.0	ethambutol