TB-Profiler result

Run: SRR2101459
Summary

Run ID: SRR2101459

Sample name:

Date: 03-04-2023 23:43:56

Number of reads: 862848

Percentage reads mapped: 99.61

Strain: lineage4.1.1.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6082 p.Lys281Asn missense_variant 0.12
gyrB 6765 p.Leu509Pro missense_variant 0.12
gyrA 6796 c.-506C>T upstream_gene_variant 0.12
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9792 p.Asn831Asp missense_variant 0.11
rpoB 762588 p.Thr928Ala missense_variant 0.14
rpoC 764355 p.Gln329Arg missense_variant 0.1
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 766603 c.3234C>T synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781435 c.-125G>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
inhA 1674469 p.Gly90Trp missense_variant 0.11
inhA 1674488 p.Gly96Val missense_variant 0.11
rpsA 1834907 p.Ser456Pro missense_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169321 p.Leu431Trp missense_variant 0.13
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
ddn 3986788 c.-56T>C upstream_gene_variant 1.0
panD 4044103 p.Ile60Asn missense_variant 0.1
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embB 4249408 c.2895G>A synonymous_variant 1.0
embB 4249784 p.Pro1091Ala missense_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407798 c.405G>T synonymous_variant 1.0