TB-Profiler result

Run: SRR22424830
Summary

Run ID: SRR22424830

Sample name:

Date: 04-04-2023 04:13:19

Number of reads: 1750610

Percentage reads mapped: 99.69

Strain: lineage4.8

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761100 p.Gln432Lys missense_variant 1.0 rifampicin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoC 764821 p.Trp484Cys missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.13
rrs 1472114 n.269A>G non_coding_transcript_exon_variant 1.0
rrs 1472504 n.659A>G non_coding_transcript_exon_variant 0.5
rrs 1472933 n.1088C>A non_coding_transcript_exon_variant 0.22
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2155687 p.Asp142Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
alr 3841609 c.-190_-189insAAGC upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246811 p.Gly100Ser missense_variant 1.0
aftB 4268571 p.Val89Ala missense_variant 0.11
whiB6 4338595 c.-75delG upstream_gene_variant 1.0