TB-Profiler result

Run: SRR5013505
Summary

Run ID: SRR5013505

Sample name:

Date: 2024-10-05T11:50:54.549849

Number of reads: 2936396

Percentage reads mapped: 51.71

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.Leu35Pro Assoc w R - Interim
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
pncA 2289138 p.Leu35Pro missense_variant 0.14 pyrazinamide Assoc w R - Interim
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
pncA 2288682 c.560G>A splice_region_variant&stop_retained_variant 0.99 pyrazinamide Not assoc w R - Interim
pncA 2289087 p.Ile52Thr missense_variant 0.14 pyrazinamide
pncA 2289242 c.-1T>C upstream_gene_variant 1.0 pyrazinamide
pncA 2289245 c.-4A>C upstream_gene_variant 1.0 pyrazinamide