TB-Profiler result

Run: SRR5485408
Summary

Run ID: SRR5485408

Sample name:

Date: 18-08-2022 08:28:04

Number of reads: 102920

Percentage reads mapped: 99.41

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
katG 2155167 p.Ser315Thr missense_variant 0.27 isoniazid
pncA 2289180 p.Val21Gly missense_variant 0.2 pyrazinamide
pncA 2289220 p.Asp8Asn missense_variant 0.2 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rpoB 761228 p.Tyr474* stop_gained 0.2
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.27
katG 2155091 p.Trp341Gly missense_variant 0.17
katG 2155097 p.Tyr339Asp missense_variant 0.25
katG 2155098 c.1014C>A synonymous_variant 0.33
pncA 2288924 p.Phe106Val missense_variant 0.18
embB 4247466 p.Asn318Thr missense_variant 0.16