TB-Profiler result

Run: SRR5485412
Summary

Run ID: SRR5485412

Sample name:

Date: 18-08-2022 08:27:41

Number of reads: 100739

Percentage reads mapped: 91.21

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155167 p.Ser315Thr missense_variant 0.15 isoniazid
pncA 2289190 p.Ser18Pro missense_variant 0.17 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6640 c.-662A>G upstream_gene_variant 0.15
rpoB 761218 p.Pro471Leu missense_variant 0.18
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.27
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.34
fabG1 1673383 c.-57T>C upstream_gene_variant 0.17
katG 2155097 p.Tyr339Asp missense_variant 0.31
katG 2155098 c.1014C>A synonymous_variant 0.23
katG 2155174 p.Ile313Ser missense_variant 0.23
embB 4247356 c.843C>T synonymous_variant 0.18
embB 4247572 c.1059A>T synonymous_variant 0.15