TB-Profiler result

Run: SRR5485449
Summary

Run ID: SRR5485449

Sample name:

Date: 18-08-2022 08:31:36

Number of reads: 161636

Percentage reads mapped: 98.96

Strain:

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrB 6621 p.Asp461Ala missense_variant 0.14 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289201 p.Cys14Tyr missense_variant 0.13 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6623 p.Ser462Pro missense_variant 0.14
gyrB 6635 p.Ser466Pro missense_variant 0.14
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.28
fabG1 1673396 c.-44A>G upstream_gene_variant 0.2
katG 2155097 p.Tyr339Asp missense_variant 0.19
katG 2155098 c.1014C>A synonymous_variant 0.19
embB 4247348 p.Thr279Pro missense_variant 0.15