TB-Profiler result

Run: SRR5485465
Summary

Run ID: SRR5485465

Sample name:

Date: 18-08-2022 08:30:07

Number of reads: 101165

Percentage reads mapped: 93.45

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.82 streptomycin
katG 2155168 p.Ser315Thr missense_variant 0.92 isoniazid
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6540 p.Asp434Ala missense_variant 0.18
gyrB 6615 p.Glu459Gly missense_variant 0.18
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.28
pncA 2289051 p.Tyr64Ser missense_variant 0.17