TB-Profiler result

Run: SRR5485469
Summary

Run ID: SRR5485469

Sample name:

Date: 18-08-2022 08:30:07

Number of reads: 125790

Percentage reads mapped: 99.11

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289114 p.His43Pro missense_variant 0.2 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7625 c.324G>A synonymous_variant 0.17
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.39
embB 4247468 p.Tyr319His missense_variant 0.2
embB 4247484 p.Gly324Ala missense_variant 0.14