TB-Profiler result

Run: SRR5485518
Summary

Run ID: SRR5485518

Sample name:

Date: 18-08-2022 08:33:28

Number of reads: 249734

Percentage reads mapped: 99.08

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761101 p.Gln432Leu missense_variant 0.5 rifampicin
rpoB 761155 p.Ser450Leu missense_variant 0.52 rifampicin
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.32 streptomycin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 0.65 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288782 p.Arg154Gly missense_variant 0.5 pyrazinamide
eis 2715344 c.-12C>T upstream_gene_variant 0.4 kanamycin
eis 2715369 c.-37G>T upstream_gene_variant 0.6 kanamycin
embB 4247574 p.Asp354Ala missense_variant 0.54 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rpsL 781705 p.Leu49Pro missense_variant 0.2
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.18
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.4
rrs 1472739 n.894A>G non_coding_transcript_exon_variant 0.17