TB-Profiler result

Run: SRR5485547
Summary

Run ID: SRR5485547

Sample name:

Date: 18-08-2022 08:27:01

Number of reads: 107316

Percentage reads mapped: 99.08

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289114 p.His43Pro missense_variant 0.18 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7585 p.Ser95Thr missense_variant 1.0
rrs 1472301 n.456C>G non_coding_transcript_exon_variant 0.18
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.29
rrs 1473240 n.1395C>T non_coding_transcript_exon_variant 0.14
rrs 1473298 n.1453A>G non_coding_transcript_exon_variant 0.14
katG 2155220 c.892T>C synonymous_variant 0.14
pncA 2288916 p.Val109Gly missense_variant 0.18
pncA 2288924 p.Phe106Leu missense_variant 0.18
pncA 2289055 p.Asp63Tyr missense_variant 0.18
pncA 2289100 p.Lys48Gln missense_variant 0.18
pncA 2289209 c.33C>T synonymous_variant 0.18