TB-Profiler result

Run: SRR5485548
Summary

Run ID: SRR5485548

Sample name:

Date: 18-08-2022 08:27:01

Number of reads: 102183

Percentage reads mapped: 99.05

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Tyr missense_variant 1.0 rifampicin
rrs 1472362 n.517C>T non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155130 p.Trp328Gly missense_variant 0.15 isoniazid
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.23
katG 2155097 p.Tyr339Asp missense_variant 0.15
katG 2155098 c.1014C>A synonymous_variant 0.17
katG 2155134 c.978G>T synonymous_variant 0.15
pncA 2288916 p.Val109Gly missense_variant 0.17
pncA 2289181 p.Val21Ile missense_variant 0.16