TB-Profiler result

Run: SRR5485552
Summary

Run ID: SRR5485552

Sample name:

Date: 18-08-2022 08:26:40

Number of reads: 110292

Percentage reads mapped: 99.04

Strain:

Drug-resistance: MDR-TB

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288931 c.297_310delCACCGGAGCGTACA frameshift_variant 1.0 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
embB 4247496 p.Asp328Gly missense_variant 0.15 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6503 p.Lys422Gln missense_variant 0.2
gyrB 6744 p.Val502Gly missense_variant 0.18
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.18
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.26
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.13
pncA 2288828 c.414T>C synonymous_variant 0.15
pncA 2288903 c.339C>G synonymous_variant 0.18
pncA 2289151 p.Ile31Leu missense_variant 0.21