TB-Profiler result

Run: SRR5485554
Summary

Run ID: SRR5485554

Sample name:

Date: 18-08-2022 08:26:39

Number of reads: 136241

Percentage reads mapped: 99.26

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247429 p.Met306Leu missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6594 p.Lys452Arg missense_variant 0.15
gyrA 7635 p.Gly112Ser missense_variant 0.54
gyrA 7644 p.Asn115Asp missense_variant 0.15
gyrA 7647 p.Phe116Leu missense_variant 0.15
gyrA 7668 p.Pro123Ser missense_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.17
fabG1 1673398 c.-42A>C upstream_gene_variant 0.17
katG 2155097 p.Tyr339Asp missense_variant 0.18
katG 2155277 p.Gly279Cys missense_variant 0.15
pncA 2289138 p.Leu35Arg missense_variant 0.25
embB 4247348 p.Thr279Pro missense_variant 0.18