TB-Profiler result

Run: SRR5485576

Summary

Run ID: SRR5485576

Sample name:

Date: 18-08-2022 08:25:04

Number of reads: 117785

Percentage reads mapped: 99.41

Strain:

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 0.93 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289039 p.Trp68* stop_gained 0.22 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6757 c.-545C>A upstream_gene_variant 0.2
rpoB 761228 p.Tyr474* stop_gained 0.15
rpsL 781661 p.Cys34Trp missense_variant 0.16
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.31
rrs 1473208 n.1363G>A non_coding_transcript_exon_variant 0.31
katG 2155076 p.Ser346Gly missense_variant 0.18
pncA 2289052 p.Tyr64His missense_variant 0.13