TB-Profiler result

Run: SRR5485578
Summary

Run ID: SRR5485578

Sample name:

Date: 2024-10-04T13:41:30.427661

Number of reads: 120787

Percentage reads mapped: 99.22

Median coverage: 0.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
isoniazid katG p.Trp300Gly Uncertain significance Mutation from literature
ethambutol
pyrazinamide pncA c.28delC Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761110 p.Asp435Val missense_variant 1.0 rifampicin Assoc w R
katG 2155214 p.Trp300Gly missense_variant 1.0 isoniazid Uncertain significance Mutation from literature
pncA 2289213 c.28delC frameshift_variant 0.5 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rrs 1472585 n.740A>C non_coding_transcript_exon_variant 0.85 kanamycin
capreomycin
streptomycin
amikacin