TB-Profiler result

Run: SRR5485594

Summary

Run ID: SRR5485594

Sample name:

Date: 18-08-2022 08:23:27

Number of reads: 86616

Percentage reads mapped: 98.91

Strain:

Drug-resistance: MDR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288957 p.Tyr95* stop_gained 0.77 pyrazinamide
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 6634 c.-668T>C upstream_gene_variant 0.14
gyrB 6641 p.Lys468Glu missense_variant 0.14
gyrA 7637 c.336C>A synonymous_variant 0.17
gyrA 7638 p.Gln113* stop_gained 0.17
rpoB 761228 p.Tyr474* stop_gained 0.2
rrs 1472314 n.471delT non_coding_transcript_exon_variant 0.2
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.33
pncA 2288924 p.Phe106Leu missense_variant 0.23
pncA 2289052 p.Tyr64His missense_variant 0.15
embB 4247401 c.888T>C synonymous_variant 0.15