TB-Profiler result

Run: SRR5485595

Summary

Run ID: SRR5485595

Sample name:

Date: 18-08-2022 08:23:27

Number of reads: 82395

Percentage reads mapped: 99.15

Strain:

Drug-resistance: RR-TB


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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761101 p.Gln432Arg missense_variant 1.0 rifampicin
rpsL 781822 p.Lys88Arg missense_variant 1.0 streptomycin
rrs 1472723 n.878G>A non_coding_transcript_exon_variant 0.14 streptomycin
embB 4247431 p.Met306Ile missense_variant 0.15 ethambutol
embB 4247465 p.Asn318His missense_variant 0.2 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7623 p.Pro108Ser missense_variant 0.2
gyrA 7647 p.Phe116Leu missense_variant 0.2
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.28
rrs 1473208 n.1363G>A non_coding_transcript_exon_variant 0.18
rrs 1473216 n.1371C>G non_coding_transcript_exon_variant 0.18
rrs 1473245 n.1400C>T non_coding_transcript_exon_variant 0.18
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.18
rrs 1473266 n.1421A>G non_coding_transcript_exon_variant 0.18
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.18
rrl 1473393 n.-265A>G upstream_gene_variant 0.14
rrl 1473412 n.-245delG upstream_gene_variant 0.14
pncA 2289160 p.Ala28Thr missense_variant 1.0
pncA 2289168 p.Ala25Asp missense_variant 0.18
embB 4247352 p.Asp280Ala missense_variant 0.15
embB 4247448 p.His312Pro missense_variant 0.23
embB 4247503 p.Phe330Leu missense_variant 1.0