TB-Profiler result

Run: SRR5485599
Summary

Run ID: SRR5485599

Sample name:

Date: 18-08-2022 08:23:05

Number of reads: 83100

Percentage reads mapped: 98.54

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761110 p.Asp435Val missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288927 c.314dupG frameshift_variant 0.55 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6632 p.Gly465Ser missense_variant 0.17
gyrA 7593 p.Arg98Cys missense_variant 0.2
gyrA 7615 p.Leu105Pro missense_variant 0.2
gyrA 7650 p.Gly117Cys missense_variant 0.2
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.29
rrs 1473345 n.1500A>G non_coding_transcript_exon_variant 0.54