TB-Profiler result

Run: SRR5485605
Summary

Run ID: SRR5485605

Sample name:

Date: 18-08-2022 08:22:42

Number of reads: 201482

Percentage reads mapped: 99.28

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 1.0 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2289214 p.Gln10Lys missense_variant 0.66 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6503 p.Lys422Gln missense_variant 0.2
gyrA 7594 p.Arg98His missense_variant 0.18
gyrA 7667 c.366C>T synonymous_variant 0.18
rpoB 761228 p.Tyr474* stop_gained 0.17
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.2
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.28
katG 2155097 p.Tyr339Asp missense_variant 0.18
embB 4247699 p.Met396Leu missense_variant 0.2