TB-Profiler result

Run: SRR5485615
Summary

Run ID: SRR5485615

Sample name:

Date: 18-08-2022 08:21:58

Number of reads: 87548

Percentage reads mapped: 99.07

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761139 p.His445Asp missense_variant 1.0 rifampicin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247466 p.Asn318Ser missense_variant 0.14 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6629 p.Gly464Ser missense_variant 0.14
gyrA 6640 c.-662A>G upstream_gene_variant 0.14
rpoB 761228 p.Tyr474* stop_gained 0.2
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.25
rrs 1472652 n.807A>C non_coding_transcript_exon_variant 0.13
rrs 1473256 n.1411A>G non_coding_transcript_exon_variant 0.2
rrl 1473504 n.-153delG upstream_gene_variant 0.2
eis 2715253 p.Phe27Cys missense_variant 0.2