TB-Profiler result

Run: SRR5485616
Summary

Run ID: SRR5485616

Sample name:

Date: 18-08-2022 08:21:29

Number of reads: 96207

Percentage reads mapped: 99.18

Strain:

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.95 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288973 p.Ile90Ser missense_variant 0.18 pyrazinamide
pncA 2289114 p.His43Pro missense_variant 0.2 pyrazinamide
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
rrs 1472302 n.457G>C non_coding_transcript_exon_variant 0.15
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.21
rrs 1472634 n.789T>C non_coding_transcript_exon_variant 0.14
rrs 1473211 n.1368delA non_coding_transcript_exon_variant 0.14
rrs 1473220 n.1375C>T non_coding_transcript_exon_variant 0.14
rrs 1473284 n.1439A>G non_coding_transcript_exon_variant 0.14
pncA 2288916 p.Val109Gly missense_variant 0.21
pncA 2288925 p.Phe106Cys missense_variant 0.14
pncA 2288937 p.Ala102Glu missense_variant 0.14
pncA 2288949 p.Ala98Asp missense_variant 0.14
pncA 2288964 p.Val93Gly missense_variant 0.14
pncA 2289000 p.Phe81Cys missense_variant 0.17
pncA 2289052 p.Tyr64His missense_variant 0.15
pncA 2289256 c.-15A>C upstream_gene_variant 1.0